Mucoadhesive chitosan-methylcellulose oral patches for the treatment of local mouth bacterial infections

Mucoadhesive buccal patches are dosage forms promising for successful drug delivery. They show the distinctive advantages of long residence time on the oral mucosa and increased in situ drug bioavailability. In this context, electrophoretic deposition (EPD) of chitosan (CS) has been demonstrated as...

Full description

Saved in:
Bibliographic Details
Published in:Biomaterials science 2023-04, Vol.11 (8), p.2699-271
Main Authors: Bonetti, Lorenzo, Caprioglio, Alice, Bono, Nina, Candiani, Gabriele, Altomare, Lina
Format: Article
Language:English
Subjects:
Bioavailability
Biological Availability
Biopolymers
Chitosan
Drug Delivery Systems - methods
Electrophoretic deposition
Gentamicin
Methylcellulose
Mouth
Patches (structures)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mucoadhesive buccal patches are dosage forms promising for successful drug delivery. They show the distinctive advantages of long residence time on the oral mucosa and increased in situ drug bioavailability. In this context, electrophoretic deposition (EPD) of chitosan (CS) has been demonstrated as a simple and easily tunable technique to produce mucoadhesive buccal patches. However, CS-based buccal patches may suffer from weak mucoadhesion, which can impair their therapeutic effect. In this work, methylcellulose (MC), a widely investigated biopolymer in the biomedical area, was exploited to increase the mucoadhesive characteristic of pristine CS patches. CS-MC patches were obtained in a one-pot process via EPD, and the possibility of incorporating gentamicin sulfate (GS) as a model of a broad-spectrum antibiotic in the so-obtained patches was investigated. The resulting CS-MC patches showed high stability in a water environment and superior mucoadhesive characteristic ( σ adh = 0.85 ± 0.26 kPa, W adh = 1192.28 ± 602.36 Pa mm) when compared with the CS control samples ( σ adh = 0.42 ± 0.22 kPa, W adh = 343.13 ± 268.89 Pa mm), due to both the control of the patch porosity and the bioadhesive nature of MC. Furthermore, GS-loaded patches showed no in vitro cytotoxic effects by challenging L929 cells with material extracts and noteworthy antibacterial activity on both Gram-positive and Gram-negative bacterial strains. Electrophoretic deposition allows obtaining gentamicin-loaded chitosan-methylcellulose patches (CS-MC/GS) with distinctive mucoadhesive and antibacterial characteristics, useful to treat mouth bacterial infections.
ISSN:2047-4830
2047-4849
DOI:10.1039/d2bm01540d