A 51-year-old Man with Primary Spinal Cord Germinoma

Germinomas, in particular, have a reported long-term survival rate greater than 90% with craniospinal irradiation alone.3 CNS germinomas are usually located intracranially, in suprasellar, basal ganglia, and thalamic structures.4 Primary spinal cord germinomas are very rare. A full panel of immunost...

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Bibliographic Details
Published in:Canadian journal of neurological sciences 2019-05, Vol.46 (3), p.369-371
Main Authors: Montazeripouragha, Amanallah, Schmidt, Brian, Baker, Patricia, Safneck, Janice, Dhaliwal, Perry, Pitz, Marshall, Kakumanu, Saranya, Krawitz, Sherry
Format: Article
Language:English
Subjects:
Biopsy
Cancer
Chemotherapy
Germinoma - pathology
Humans
Letter to the Editor
Lymphoma
Magnetic resonance imaging
Male
Melanoma
Metastasis
Middle Aged
Morphology
Nervous system
Spinal cord
Spinal Cord Neoplasms - pathology
Tuberculosis
Tumors
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Summary:Germinomas, in particular, have a reported long-term survival rate greater than 90% with craniospinal irradiation alone.3 CNS germinomas are usually located intracranially, in suprasellar, basal ganglia, and thalamic structures.4 Primary spinal cord germinomas are very rare. A full panel of immunostains for carcinoma/GCT narrowed the diagnosis to germinoma with the positive triad of octamer-binding transcription factor (OCT) 3/4, placental alkaline phosphatase (PLAP), and c-Kit (CD117) (Figure 2G–I), despite regionally strong cytokeratin staining (Figure 2J–K). [...]this 51-year-old East Asian man is the oldest reported patient with the rare diagnosis of primary spinal cord germinoma.
ISSN:0317-1671
2057-0155
DOI:10.1017/cjn.2019.23