Morpholine-modified permethyl β-cyclodextrin supramolecular nanoparticles for precise dual-targeted imaging

Possessing dual-targeted agents toward the lysosome and cancer cells, a ternary supramolecular assembly was constructed by a morpholine-modified permethyl β-cyclodextrin, sulfonated porphyrin, and folic acid-modified chitosan via multivalent interactions. As compared with free porphyrin, the obtaine...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-04, Vol.59 (31), p.468-4683
Main Authors: Niu, Jie, Liu, Yao-Hua, Xu, Wenshi, Xu, Wen-Wen, Song, Ya-Hui, Yu, Jie, Zhang, Ying-Ming, Liu, Yu
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Assembly
beta-Cyclodextrins
Cancer
Chitosan
Cyclodextrins
Folic acid
Morpholine
Morpholines - pharmacology
Nanoparticles
Porphyrins
Porphyrins - pharmacology
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Summary:Possessing dual-targeted agents toward the lysosome and cancer cells, a ternary supramolecular assembly was constructed by a morpholine-modified permethyl β-cyclodextrin, sulfonated porphyrin, and folic acid-modified chitosan via multivalent interactions. As compared with free porphyrin, the obtained ternary supramolecular assembly showed promoted photodynamic effect and achieved dual-targeted precise imaging in cancer cells. A supramolecular assembly was constructed by morpholine-modified permethyl β-cyclodextrin, sulfonated porphyrin, and folic acid-modified chitosan via multivalent interactions, exhibiting promoted photodynamic effect and dual-targeted precise imaging.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc00735a