Prevalence and antimicrobial susceptibility patterns of extended spectrum β-lactamase producers and non-producers Pseudomonas aeruginosa in Peshawar

Pseudomonas aeruginosa identified as one of the major pathogens responsible for nosocomial infections. The Extended Spectrum Beta Lactamases (ESBLs) enzymes production in Pseudomonas specie, have been rapidly reported all over the world. ESBLs usually known as the β-lactamase that is responsible for...

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Bibliographic Details
Published in:Pure and applied biology 2023-06, Vol.12 (2), p.769-778
Main Author: Jafar, Syed
Format: Article
Language:English
Subjects:
Amikacin
Aminoglycosides
Amoxicillin
Antibiotics
Antiinfectives and antibacterials
Carbapenems
Cefepime
Cefoperazone
Cefotaxime
Cephalosporins
Ciprofloxacin
Clavulanic acid
Climate change
Drug resistance
Fluoroquinolones
Fosfomycin
Imipenem
Laboratories
Meropenem
Nosocomial infection
Nosocomial infections
Penicillin
Pseudomonas aeruginosa
β Lactamase
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Summary:Pseudomonas aeruginosa identified as one of the major pathogens responsible for nosocomial infections. The Extended Spectrum Beta Lactamases (ESBLs) enzymes production in Pseudomonas specie, have been rapidly reported all over the world. ESBLs usually known as the β-lactamase that is responsible for resistance against Penicillin and Cephalosporins. The current research was design for the Prevalence and Antimicrobial Susceptibility Patterns of Extended Spectrum β-Lactamase Producers and Non-producers Pseudomonas aeruginosa in Peshawar. Total of 1230 samples were taken, in which 105 (8.53%) showed positive result for P. aeruginosa growth. Samples taken from females showedhigher rate (61.9%) of P. aeruginosa occurrence as compared to male (48.3%). P. aeruginosa 46.6%, were isolated from pus, 31.4% urine, 11.4% wounds, 8.5% swabs (ear, throat) and 1.9% from High Vaginal Swabs (HVS). Most of the isolates were sensitive to Carbapenems (Meropenem 84%) followed by Aminoglycosides (Amikacin 73.3%), Beta- Lactamse Inhibitor (Cefoperazone+Sulbactum 69.5%), Cephalosporins (Cefepime 60.9%), Fosfomycin (Fosfomycin 57.1%) and Fluoroquinolones (Ciprofloxacin 56.1%). Out of 105 P. aeruginosa isolates, 46 (43.8%) were ESBLs producers and 49 (46.6%) were non-ESBLs producers. It concluded that Meropenem (MEM) 82.6% and Imipenem (IMP) 80.43% showed greater sensitivity against both ESBLs-positive and non-ESBLs-negative P. aeruginosa among selected antibiotics. While, the Amoxicillin-Clavulanic acid and Cefotaxime were the least efficient drugs with a higher number of samples (88.5% and 80.9% respectively) showed resistance. The ESBLs-producing isolates showed more resistance as compared to the Non-producing P. aeruginosa isolates. Meropenem and Imipenem were found the most effective antibiotics.
ISSN:2304-2478
2304-2478
DOI:10.19045/bspab.2023.120077