Formation of Various Antimicrobial Peptide Emericellipsin Isoforms in Emericellopsos alkalina under Different Cultivation Conditions

Microbiological screening of the target component of emericellipsin A of the Emericellopsis alkalina E101 strain has been carried out in various biotechnological systems at various pHs. The content of emericellipsin A was quantified under these conditions. It has been established that the new approv...

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Bibliographic Details
Published in:Applied biochemistry and microbiology 2023-04, Vol.59 (2), p.160-167
Main Authors: Kuvarina, A. E., Sukonnikov, M. A., Rogozhin, E. A., Serebryakova, M. V., Timofeeva, A. V., Georgieva, M. L., Sadykova, V. S.
Format: Article
Language:English
Subjects:
Antimicrobial peptides
Biochemistry
Biomedical and Life Sciences
Biotechnology
Comparative analysis
Cultivation
Isoforms
Life Sciences
Medical Microbiology
Microbiology
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Summary:Microbiological screening of the target component of emericellipsin A of the Emericellopsis alkalina E101 strain has been carried out in various biotechnological systems at various pHs. The content of emericellipsin A was quantified under these conditions. It has been established that the new approved membrane-liquid cultivation method at pH 10 contributes to an increase in the yield of the main component of emericellipsin A. It has been shown that the new method of cultivating the strain E. alkalina E101 also promotes the synthesis of various isoforms of the main component of emericellipsin A. Some comparative analysis has been carried out.
ISSN:0003-6838
1608-3024
DOI:10.1134/S0003683823020060