Eupalinolide N, a Previously Undescribed Sesquiterpene Lactone with Anti-inflammatory Activity from Eupatorium lindleyanum

A previously undescribed sesquiterpene lactone, named eupalinolide N (1), was isolated from traditional Chinese medicine “Ye-Ma-Zhui” (Eupatorium lindleyanum) by ethanol reflux extraction, reduced pressure concentration, macroporous resin column chromatography, and C18 reversed-phase chromatography....

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Bibliographic Details
Published in:Records of natural products 2023-05, Vol.17 (3), p.529-535
Main Authors: Peng, Cheng, Yan, Jie, Guo, Dale, Pei, Jin, Deng, Yun, Liu, Ding, Xie, Xiaofang, Guo, Wenxiu, Zhou, Lanyu, Xiao, Bin, Huo, Xueyan, Hu, Yunjie
Format: Article
Language:English
Subjects:
Chinese medicine
Chromatography
Folk medicine
Software
Spectrum analysis
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Summary:A previously undescribed sesquiterpene lactone, named eupalinolide N (1), was isolated from traditional Chinese medicine “Ye-Ma-Zhui” (Eupatorium lindleyanum) by ethanol reflux extraction, reduced pressure concentration, macroporous resin column chromatography, and C18 reversed-phase chromatography. Its structure was elucidated by a comprehensive interpretation of spectroscopy evidence as well as ECD calculations. 1 showed anti-inflammatory activity by inhibiting the gene expressions of pro-inflammatory factors including IL-1β, TNFαCOX-2,and iNOS at the concentration of 7.5 μM, as well as attenuating the excretion of NO, IL-6, and TNF-α in Raw 264.7 macrophages at the concentration of 15 μM.
ISSN:1307-6167
1307-6167
DOI:10.25135/rnp.368.2206.2499