Real-Time, Automated, Multiobjective, Cloud Computing Whole Slide Imaging Device

We present a novel approach to whole slide imaging (WSI) that consists of a uniquely designed, low-cost, single-unit-portable, optically isolated dust-free, onboard mini-computer integrated, fully enclosed WSI scanner device that can be wirelessly controlled through an easy-to-use, intuitive user in...

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Bibliographic Details
Published in:IEEE transactions on instrumentation and measurement 2023, Vol.72, p.1-9
Main Authors: Mallick, Satya Prasanna, Adithya, K. S., Sabui, Ratul, Naidu, Balu Babu, Singh, Ranjeet, Babu, Harish, Jagadeesh, Gajula, Venkata Amaresh, K. M., Gopal, Ram, Sharma, Vandana
Format: Article
Language:English
Subjects:
Algorithms
Cloud computing
Control equipment
Health care facilities
Image processing
Low cost
Minicomputers
Portable equipment
Real time
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Summary:We present a novel approach to whole slide imaging (WSI) that consists of a uniquely designed, low-cost, single-unit-portable, optically isolated dust-free, onboard mini-computer integrated, fully enclosed WSI scanner device that can be wirelessly controlled through an easy-to-use, intuitive user interface application on an iPad. A Laboratory Virtual Instrument Engineering Workbench (LabVIEW)-based control software interfaces with multiple hardware modules within the device using the queued message handler (QMH) architecture optimized to handle synchronous and parallel real-time processes. The system scans an area of [Formula Omitted] mm2 in [Formula Omitted]5 min at a resolution of [Formula Omitted] with a [Formula Omitted] objective lens. With a low weight of 12 kg, the enclosure dimensions being [Formula Omitted] mm, and its low cost of building the device makes it more portable and affordable to the intended rural and low-tier medical centers. The instrument incorporates features such as automatic slide loading, slide registration, brightness control, slide scanning, and an autofocus algorithm implementing a unique “convolution-histogram mean value” method to determine the [Formula Omitted]-focus map. The work showcases a shift in preprocessing computations to the cloud server and integrating AI/ML tools for advanced database and image processing techniques on a portable device. A nonmedical application of studying plasma science using the instrument has also been presented, demonstrating its wider application in medical and nonmedical fields.
ISSN:0018-9456
1557-9662
DOI:10.1109/TIM.2023.3265763