Heat preservation, antifouling, hemostatic and antibacterial aerogel wound dressings for emergency treatment

Hemostatic dressings with multiple functions are superior to current hemostatic dressings for use in the complex situation of emergency accidents. In particular, the existing dressings lack consideration for the prevention of hypothermic shock after massive hemorrhage. In this study, gelatin (GN) an...

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Bibliographic Details
Published in:Frontiers of materials science 2023-06, Vol.17 (2), p.230641, Article 230641
Main Authors: Li, Fangling, Han, Xiaoman, Cao, Dongdong, Yin, Junxia, Chen, Li, Li, Dongmei, Cui, Lin, Liu, Zhiyong, Guo, Xuhong
Format: Article
Language:English
Subjects:
Aerogels
antibacterial
Antifouling
Biocompatibility
Blood
Chemistry and Materials Science
Contact angle
Crosslinking
Emergencies
Gelatin
heat preservation
Hemorrhage
hemostasis
Hemostatics
Imines
Materials Science
Nanowires
Pectin
Polydimethylsiloxane
Polyvinyl alcohol
Research Article
Silver
Substrates
Thermal energy
wound dressing
Wound healing
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Summary:Hemostatic dressings with multiple functions are superior to current hemostatic dressings for use in the complex situation of emergency accidents. In particular, the existing dressings lack consideration for the prevention of hypothermic shock after massive hemorrhage. In this study, gelatin (GN) and oxidized pectin (OP) were used for Schiff base cross-linking, and then polyvinyl alcohol (PVA) solution mixed with hemostatic caffeic acid (CA) was introduced to obtain aerogel substrate material (CB) after lyophilization. Polydimethylsiloxane (PDMS) and silver nanowires (Ag NWs) were used to construct a hydrophobic layer, an antibacterial layer and an infrared reflective layer on both sides of CB to prepare a multifunctional aerogel wound dressing with heat preservation, antifouling, hemostasis and antibacterial properties (PDMS-Ag NW-CB). The results showed that the infrared transmittance of PDMS-Ag NW-CB is almost 0, so that thermal energy loss from the body is minimized. The contact angles with water and blood are 129° and 120°, respectively, which have the effect of antifouling. This dressing can absorb blood quickly within 10 min, adhere to and gather platelets, and achieve hemostasis. It has good antibacterial and biocompatibility. Therefore, PDMS-Ag NW-CB has great potential in application to emergency treatment.
ISSN:2095-025X
2095-0268
DOI:10.1007/s11706-023-0641-0