The Brain Basis of Comorbidity in Neurodevelopmental Disorders

Purpose of Review Research examining brain development in neurodevelopmental disorders has largely comprised small-scale studies on individual disorders. Findings have confirmed neurodevelopmental disruption and deviation; however, comorbidity between disorders continues to challenge our understandi...

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Bibliographic Details
Published in:Current developmental disorders reports 2019-03, Vol.6 (1), p.9-18
Main Authors: Licari, Melissa K., Finlay-Jones, Amy, Reynolds, Jess E., Alvares, Gail A., Spittle, Alicia J., Downs, Jenny, Whitehouse, Andrew J. O., Leonard, Helen, Evans, Kiah L., Varcin, Kandice
Format: Article
Language:English
Subjects:
Attention deficit hyperactivity disorder
Autism
Brain research
Comorbidities (D Dewey
Comorbidity
Etiology
Family Medicine
General Practice
Medicine
Medicine & Public Health
Neurodevelopmental disorders
Pediatrics
Psychiatry
Section Editor
Topical Collection on Comorbidities
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Summary:Purpose of Review Research examining brain development in neurodevelopmental disorders has largely comprised small-scale studies on individual disorders. Findings have confirmed neurodevelopmental disruption and deviation; however, comorbidity between disorders continues to challenge our understanding of brain-behaviour associations. This review discusses early brain development and the etiological factors that may give rise to atypical developmental trajectories, along with neuroimaging insights into neurodevelopmental disorders. Recent Findings Evidence related to the behavioural, neurological, genetic and environmental factors impacting on brain development is examined. Large neuroimaging databases are currently being used to identify early alterations in brain development and areas of divergence and convergence between disorders are reviewed. Summary Investigative approaches based on diagnostic groups continue to challenge our ability to elucidate regions of the brain linked to behavioural phenotypes, especially those known to be shared across disorders.
ISSN:2196-2987
2196-2987
DOI:10.1007/s40474-019-0156-7