Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants

Hypertension is a predisposing factor for cardiovascular disease (CVD). The extant literature regarding the effects of folic acid supplementation on blood pressure (BP) is inconsistent. Therefore, this systematic review and meta-analysis of randomized controlled trials was conducted to summarize the...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2023, Vol.63 (13), p.1846-1861
Main Authors: Asbaghi, Omid, Salehpour, Sara, Rezaei Kelishadi, Mahnaz, Bagheri, Reza, Ashtary-Larky, Damoon, Nazarian, Behzad, Mombaini, Delsa, Ghanavati, Matin, Clark, Cain C. T., Wong, Alexei, Naeini, Amirmansour Alavi
Format: Article
Language:English
Subjects:
Acids
Blood Pressure
Body weight
Cardiovascular diseases
Cardiovascular Diseases - prevention & control
Clinical trials
Dietary Supplements - adverse effects
Female
folate
Folic Acid
Heart diseases
Humans
Hypertension
Hypertension - drug therapy
Male
Meta-analysis
Overweight
Regression analysis
Statistical analysis
Subgroups
Supplements
Systematic review
Vitamin B
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Summary:Hypertension is a predisposing factor for cardiovascular disease (CVD). The extant literature regarding the effects of folic acid supplementation on blood pressure (BP) is inconsistent. Therefore, this systematic review and meta-analysis of randomized controlled trials was conducted to summarize the effects of folic acid supplementation on BP. A systematic search was carried out in PubMed, Scopus, ISI Web of Science, and Cochrane library, from database inception to August 2021. Data were pooled using the random-effects method and were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). The pooled results of 22 studies, including 41,633 participants, showed that folic acid supplementation significantly decreased systolic BP (SBP) (WMD: −1.10 mmHg; 95% CI: −1.93 to −0.28; p = 0.008). Subgroup analysis showed that the results remained significant when baseline SBP was ≥120 mmHg, intervention duration was ≤6 weeks, intervention dose was ≥5 mg/d, in patients with CVD, males and females, and overweight participants, respectively. Furthermore, the changes observed in diastolic BP (DBP) (WMD: −0.24 mmHg; 95% CI: −0.37 to −0.10; p 6 weeks), low dose of folic acid (
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2021.1968787