Advances in Biohybridized Planar Polymer Membranes and Membrane‐Like Matrices

• Published in: Helvetica chimica acta 2023-04, Vol.106 (4), p.n/a
• Main Authors: Eggenberger, Olivia M., Jaśko, Piotr, Tarvirdipour, Shabnam, Schoenenberger, Cora‐Ann, Palivan, Cornelia G.
• Format: Article
• Language: English
• Subjects: biofunctionalization; biohybridization; Biomimetics; Biomolecules; Membrane proteins; Membranes; planar polymer membranes; Platforms; Polymers
• ISSN: 0018-019X; 1522-2675
• DOI: 10.1002/hlca.202200164

The past few decades have seen increasing growth in the field of biomimetic membranes and thus also a rapid expansion of their biomedical and technological applications. Versatility, stability and scalability have moved biohybrid polymer membranes into the limelight. This review focuses on planar, soft polymer membranes and polymer‐based matrices and their role as a host for different types of biomolecules. Because biomimetic polymer platforms present an extensive, ever‐growing field, we limit ourselves mostly to the discussion of producing planar polymer membranes on solid supports that lend themselves to functionalization by biomolecules. We present an overview of the major highlights and challenges associated with the biohybridization of such polymer platforms. In particular, we elaborate on procedures developed to maintain optimal peptide and membrane protein performance in a customized polymer membrane or membrane‐like environment. Finally, we discuss a number of applications of such biohybridized polymer platforms and contemplate future developments to further exploit their potential.