Essential Oils of Two Portuguese Endemic Species of Lavandula as a Source of Antifungal and Antibacterial Agents

Chemical investigations of L. stoechas subsp. luisieri and L. pedunculata essential oils were analyzed by GC-MS, and the antimicrobial activity was performed against bacteria and fungi isolated from food sources. The cytotoxicity of the essential oil was performed in NHDF cells using the MTT method....

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Bibliographic Details
Published in:Processes 2023-04, Vol.11 (4), p.1165
Main Authors: Domingues, Joana, Goulão, Manuela, Delgado, Fernanda, Gonçalves, José Carlos, Gonçalves, Joana, Pintado, Cristina Santos
Format: Article
Language:English
Subjects:
Acetic acid
Antibacterial agents
Antifungal activity
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Bacteria
Camphor
Cell viability
Chromatography
Cytotoxicity
Endemic species
Essential oils
Food sources
Fungicides
Gram-negative bacteria
Gram-positive bacteria
Hydrocarbons
Laboratories
Lavandula
Lavandula luisieri
Lavandula pedunculata
Lavandula stoechas
Mass spectrometry
Metabolites
Microorganisms
Minimum inhibitory concentration
Oils & fats
Scientific imaging
Toxicity
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Summary:Chemical investigations of L. stoechas subsp. luisieri and L. pedunculata essential oils were analyzed by GC-MS, and the antimicrobial activity was performed against bacteria and fungi isolated from food sources. The cytotoxicity of the essential oil was performed in NHDF cells using the MTT method. According to the results, the main compounds of L. stoechas subsp. luisieri essential oil were trans-α-necrodyl acetate (40.2%), lavandulyl acetate (11%), and trans-α-necrodol (10.4%), while fenchone (50.5%) and camphor (30.0%) in L. pedunculata essential oil. The antifungal activity of essential oils was confirmed with MIC values ranging from 1.2 to 18.7 µL/mL; for bacteria, it ranged from 4.7 to 149.3 µL/mL. Both the Lavandula species tested showed low or equal MIC and MBC/MFC values for L. stoechas subsp. luisieri essential oil, revealing greater efficacy in antimicrobial activity. The L. stoechas subsp. luisieri essential oil revealed cytotoxic effects (30 ± 2% of cell viability) in NHDF cells at all concentrations tested.
ISSN:2227-9717
2227-9717
DOI:10.3390/pr11041165