Advances in synthesis and biological activities of benzotriazole analogues: A micro review

Although the first synthesis of benzotriazole was performed in the 19th century still new methods for their preparation have developed. In this micro review authors focus mostly on the various synthetic strategies developed so far to synthesize benzotriazole and its derivatives by different strategi...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2023-05, Vol.60 (5), p.705-742
Main Authors: Bollikolla, Hari Babu, Boddapati, S. N. Murthy, Thangamani, Swetha, Mutchu, Baby Ramana, Alam, Mohammed Mujahid, Hussien, Mohamed, Jonnalagadda, Sreekantha Babu
Format: Article
Language:English
Subjects:
Benzotriazole
Cycloaddition
Synthesis
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Summary:Although the first synthesis of benzotriazole was performed in the 19th century still new methods for their preparation have developed. In this micro review authors focus mostly on the various synthetic strategies developed so far to synthesize benzotriazole and its derivatives by different strategies, such as metal‐free, metal‐assisted [3 + 2] cycloaddition reactions, cyclocondensations, flow methods, heterocyclizations, and so forth. This micro review combines recent (2005–2022 till date) information on the strategies used for the synthesis of benzotriazoles. Moreover, a brief overview of the bio applications of the benzotriazole scaffold along with pharmacological activity is also discussed. Some bioactive benzotriazole analogs.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4587