Study on Preparation of Y-90 Microspheres in Da Lat Nuclear Reactor for Application in Treatment of Primary and Secondary Liver Cancers

In this article, Y-90 microspheres are synthesized in three forms (resin microspheres, glass microspheres and gel microspheres) in Da Lat Nuclear Reactor (Vietnam) with a capacity of 500 kW for application in treatment of primary and secondary liver cancers. Characterization and quality of Y-90 micr...

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Bibliographic Details
Published in:Oriental journal of chemistry 2020-01, Vol.36 (4), p.695-702
Main Authors: Thanh Minh, Pham, Dong, Duong Van, Thuan, Le Van, Minh Tri, Truong, Toan, Truong Duc, Vu, Cao Dong
Format: Article
Language:English
Subjects:
Cancer therapies
Endotoxins
Field emission microscopy
Heavy metals
Liver cancer
Microspheres
Neutrons
Nuclear reactors
Purity
Quality standards
Radiochemistry
Radioisotopes
Resins
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Summary:In this article, Y-90 microspheres are synthesized in three forms (resin microspheres, glass microspheres and gel microspheres) in Da Lat Nuclear Reactor (Vietnam) with a capacity of 500 kW for application in treatment of primary and secondary liver cancers. Characterization and quality of Y-90 microspheres are checked by field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), chemical purity, radionuclide purity, radiochemical purity, sterility, bacterial endotoxins, toxic heavy metals (ICP-MS) and product stability over time. The results showed that Y-90 resin microspheres, Y-90 glass microspheres and Y-90 gel microspheres with particle sizes of 20-30 µm have a high specific activity to meet the quality standards of radiopharmaceuticals according to British Pharmacopoeia 2016. This is a promising radiopharmaceuticals in treatment of primary and secondary liver cancers using radioembolization in Vietnam.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/360414