A Comparative Study on Biological Activity of Schiff bases Derived from 2-(2-amino)-3-(1H-indol-3-yl)propanoic acid

Indole group containing four different Schiff bases such as 2-((2-hydroxybenzylidene)amino)-3-(1H-indol-3-yl)propanoic acid, 2,2'-((1Z,1'E)-(1,4-phenylenebis(methanylylidene))bis(azanylylidene))bis(3-(3a,7a-dihydro-1H-indol-3-yl)propanoic acid), (E)-2-((4-chlorobenzylidene)amino)-3-(3a,7a-...

Full description

Saved in:
Bibliographic Details
Published in:Oriental journal of chemistry 2020-01, Vol.36 (4), p.780-787
Main Authors: Radhakrishnan, Santhi, Balakrishnan, Rajeswari, Selvaraj, Ahalya
Format: Article
Language:English
Subjects:
19th century
Aldehydes
Biological activity
Chloride
Comparative studies
Fungicides
Imines
NMR
Nuclear magnetic resonance
Polyanilines
Polymers
Potassium
Propionic acid
Protons
Solvents
Tryptophan
Tuberculosis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Indole group containing four different Schiff bases such as 2-((2-hydroxybenzylidene)amino)-3-(1H-indol-3-yl)propanoic acid, 2,2'-((1Z,1'E)-(1,4-phenylenebis(methanylylidene))bis(azanylylidene))bis(3-(3a,7a-dihydro-1H-indol-3-yl)propanoic acid), (E)-2-((4-chlorobenzylidene)amino)-3-(3a,7a-dihydro-1H-indol-3-yl)propanoic acid were synthesized from Tryptophan and respective aldehydes namely Salicylaldehyde, Terephthalaldehyde, 2-Chlorobenzaldehyde and 4-Chlorobenzaldehyde. A polymeric composite was prepared by doping the Schiff base derived from salicylaldehyde on polyaniline chloride. These compounds were characterized by Fourier –transform infrared (FTIR), UV-Visible, 1H- NMR spectroscopic techniques. The Schiff Bases and polymer have been examined for their antimicrobial activity. Antibacterial and antifungal activities of all the compounds were studied by Kirby Bauer Agar well diffusion method. In addition Anti-Tubercular study was also performed. It has been found that all the five compounds have remarkable antimicrobial activity.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/360426