Synthesis, Characterization and Evaluation of Biological Activities of Sn(II) Complexes of Schiff Base Incorporating Sulpha Drugs

In this study, we report synthesis, characterization and biological activities of four sulpha drug based Schiff base ligands and their Sn(II) complexes. The Schiff bases and their Sn(II) complexes have been synthesized by traditional methods and characterized by the spectral techniques IR, NMR (1H a...

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Bibliographic Details
Published in:Oriental journal of chemistry 2021-12, Vol.37 (6), p.1387-1395
Main Authors: Meena, Kiran, Shekhawat, Virendra Singh, Varshney, Sarita, Varshney, A K
Format: Article
Language:English
Subjects:
Dichlorides
Differential thermal analysis
Dilution
Drugs
E coli
Ethanol
Fungicides
Imines
Infectious diseases
Ligands
Malaria
Microorganisms
NMR
Nuclear magnetic resonance
Solvents
Spectral methods
Synthesis
Tin
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Summary:In this study, we report synthesis, characterization and biological activities of four sulpha drug based Schiff base ligands and their Sn(II) complexes. The Schiff bases and their Sn(II) complexes have been synthesized by traditional methods and characterized by the spectral techniques IR, NMR (1H and 13C), mass and TGA-DTA. Newly synthesized Schiff bases (L1-L4) and their Sn(II) complexes (C-1 to C-4) have been screened for antibacterial activity against bacterial strains S. aureus, S. pyogenus, E. coli, P. aeruginosa and antifungal activity against fungal strains C. albicans, A. niger, A. clavatus using broth micro dilution method. Best antimicrobial activity was shown by C-3 complex against E. coli (MIC, 50.0 µg/mL) and A. niger microbial strains (MIC, 100 µg/mL). Moreover, antimalarial activity against plasmodium falciparum was also studied. Complex C-3 was found to be more active against parasite P. falciparum (IC50, 0.04 µg/mL). Results showed that dichloride tin complexes are more active with respect to their corresponding Schiff base ligands.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/370617