Structural, Spectroscopic, Molecular Docking and Biological Evaluation of some Novel Benzofuran Derivatives

Benzofurans display a wide array of pharmaceutical activities. The present work incorporates the synthesis of some novel benzofuran derivatives. The compound 1 (z)-3-amino-7methoxy-N1-(2-oxoindolin-3-yliedene)benzofuran-2-carbohydrazide was synthesized by refluxing carbohydrazide and isatin. The com...

Full description

Saved in:
Bibliographic Details
Published in:Oriental journal of chemistry 2022-12, Vol.38 (6), p.1498-1504
Main Authors: Netravati, Lambani Narayana, Basavaraja, Kalapura Mathada, Shilpa, Kondareddy Gopinath, Bharathi, Sharanappa Veerapur
Format: Article
Language:English
Subjects:
Dihydrofolate reductase
Ethanol
Fungicides
Ligands
Molecular docking
Proteins
Refluxing
Spectral methods
Synthesis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Benzofurans display a wide array of pharmaceutical activities. The present work incorporates the synthesis of some novel benzofuran derivatives. The compound 1 (z)-3-amino-7methoxy-N1-(2-oxoindolin-3-yliedene)benzofuran-2-carbohydrazide was synthesized by refluxing carbohydrazide and isatin. The compound 1 formed the key intermediate for the synthesis of compounds 2a-c. The structures of prepared derivatives were established by physical and spectral methods such as elemental analysis, FTIR, 1HNMR and Mass. The molecular docking studies was performed to detect the behavior of compounds towards target proteins. The derivatives were further screened for antibacterial and antifungal analysis.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/380623