Effect of the dinitrosyl iron complex with N-ethylthiourea on ROS and NO intracellular levels and caspase activity in HeLa tumor cells

The kinetics of intracellular accumulation of nitrogen monoxide and reactive oxygen species under the action of various concentrations of the dinitrosyl iron complex with N -ethylthiourea was described for the first time in in vitro experiments. Both a significant accumulation of NO by HeLa tumor ce...

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Bibliographic Details
Published in:Russian chemical bulletin 2023-04, Vol.72 (4), p.1066-1074
Main Authors: Amozova, V. I., Balakina, A. A., Mishchenko, D. V., Sanina, N. A.
Format: Article
Language:English
Subjects:
Accumulation
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Inorganic Chemistry
Iron
Nitric oxide
Nitrogen
Organic Chemistry
Oxygen
Tumors
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Summary:The kinetics of intracellular accumulation of nitrogen monoxide and reactive oxygen species under the action of various concentrations of the dinitrosyl iron complex with N -ethylthiourea was described for the first time in in vitro experiments. Both a significant accumulation of NO by HeLa tumor cells and a substantial increase in the generation of intracellular reactive oxygen species under the action of the complex were shown. A decrease in the viability of tumor cells was revealed accompanied by an increase in the activity of proapoptotic enzymes of caspase 3 and caspase 8 after 6 h of the complex action. The data obtained suggest an important role of reactive oxygen species and reactive nitrogen species in the cytotoxic effect of the dinitrosyl iron complex with N -ethylthiourea on the tumor cells.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-023-3872-9