One-Pot Synthesis of 3-Carbamoyl-2-oxo-1,2-dihydropyridine-4-carboxylic Acids

A one-pot synthesis of 3-carbamoyl-2-oxo-1,2-dihydropyridine-4-carboxylic acids has been developed via the reaction of 4-oxoalkane-1,1,2,2-tetracarbonitriles with water, followed by alkaline hydrolysis of the resulting mixture of 2-oxo-1,2-dihydropyridine-3,4-dicarbonitrile and 2-oxo-4-cyano-1,2-dih...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2023-03, Vol.59 (3), p.536-539
Main Authors: Fedoseev, S. V., Lipin, K. V., Ershov, O. V.
Format: Article
Language:English
Subjects:
Carboxylic acids
Chemistry
Chemistry and Materials Science
Organic Chemistry
Synthesis
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Summary:A one-pot synthesis of 3-carbamoyl-2-oxo-1,2-dihydropyridine-4-carboxylic acids has been developed via the reaction of 4-oxoalkane-1,1,2,2-tetracarbonitriles with water, followed by alkaline hydrolysis of the resulting mixture of 2-oxo-1,2-dihydropyridine-3,4-dicarbonitrile and 2-oxo-4-cyano-1,2-dihydropyri­dine-3-carboxamide.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428023030223