Diffusion tensor imaging: a smart move to olfactory pathway imaging; comparative study of chronic sinonasal polyposis patients and normal control

Background Olfaction is critically important for a good quality of life and incorporated in many physiological domains such as attention, emotion, memory, and airflow motor control. Olfactory researches have been expanded in the last decade due to close relation between the olfactory disorders and d...

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Bibliographic Details
Published in:Egyptian journal of radiology and nuclear medicine 2020-02, Vol.51 (1), p.34-8
Main Authors: Taha, Tougan, Megahed, Ayah A, Taha, Mohamed Shehata, Mahmoud, Heba, Rabie, Tahany Mohamed, Askora, Anas Mohamed
Format: Article
Language:English
Subjects:
Alzheimer's disease
Comparative analysis
Diagnostic imaging
Localization
Magnetic resonance imaging
Medical research
Medicine, Experimental
Olfaction disorders
Parkinson's disease
Patients
Physiological aspects
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Summary:Background Olfaction is critically important for a good quality of life and incorporated in many physiological domains such as attention, emotion, memory, and airflow motor control. Olfactory researches have been expanded in the last decade due to close relation between the olfactory disorders and different brain diseases. Diagnosis of anosmia and hyposmia are based on history, smell tests, and physical examination which rely on the patient's response without an objective measure of impairment. This study assessed the value of volumetry and DTI parameters as objective measurements for olfactory dysfunction. Fourteen patients with chronic sinonasal polyposis for at least 6 months were included in this study; all of them underwent tailored MRI examination including volumetry and DTI for olfactory bulbs and tracts. The results were compared to the same number of age and sex-matched healthy control group. Results The study results showed that olfactory bulb and tract (OB/T) volume, FA and ADC could distinguish between patients and healthy controls. Statistically significant differences were noticed between the FA & ADC values of patient and control groups (p < 0.05) and a highly significant one was noticed as regarding the OT volume (p < 0.001). Conclusion MR volumetry and DTI parameters can be used as objective measurements for the olfactory dysfunction for patients with chronic sinonasal polyposis.
ISSN:0378-603X
2090-4762
DOI:10.1186/s43055-020-0140-6