3′‐O‐(2‐Nitrobenzenesulfonyl)fluorescein as a Fluorescent Probe for Hydrogen Polysulfides by Straightforward One‐Step Deprotection

Invited for this month's cover is the group of Prof. Hatsuo Maeda at Hyogo Medical University, Japan. The cover picture features selective visualization of hydrogen polysulfides (H2Sn, n ≥ 2) over other related species through a fluorogenic reaction of 3′‐O‐(2‐nitrobenzenesulfonyl)fluorescein,...

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Bibliographic Details
Published in:Analysis & sensing 2023-05, Vol.3 (3), p.n/a
Main Authors: Tsukamoto, Koji, Ohsawa, Hikaru, Nishiyama, Ryosuke, Maeda, Hatsuo
Format: Article
Language:English
Subjects:
Fluorescein
Fluorescent indicators
Hydrogen
Polysulfides
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Summary:Invited for this month's cover is the group of Prof. Hatsuo Maeda at Hyogo Medical University, Japan. The cover picture features selective visualization of hydrogen polysulfides (H2Sn, n ≥ 2) over other related species through a fluorogenic reaction of 3′‐O‐(2‐nitrobenzenesulfonyl)fluorescein, that was screened as the best practical H2Sn probe among 2‐ or 4‐nitrobenzenesulfonylated fluorescein derivatives. More information can be found in the Research Article by K. Tsukamoto, H. Maeda, and co‐workers. 3′‐O‐(2‐Nitrobenzenesulfonyl)fluorescein (1 c) was demonstrated to function as a fluorescent probe for hydrogen polysulfides (H2Sn, n≥2) by straightforward one‐step deprotection, and its high selectivity and sensitivity toward H2Sn allowed the practical application of 6′‐O‐acetylated 1 c (i. e., 3 c) to the fluorescent imaging of H2Sn in HeLa cells. Read more about the story behind the cover in the Cover Profile and about the research itself (DOI: 10.1002/anse.202200084).
ISSN:2629-2742
2629-2742
DOI:10.1002/anse.202300006