Ionic Liquid [(EMIM)Ac] Catalyzed Green and Efficient Synthesis of Pyrano[2,3-c]Pyrazole Derivatives

A Green, efficient and clean route for synthesis of biologically potent pyrano[2,3-c]pyrazole derivatives has been developed in excellent yield, by using biodegradable ionic liquid 1-ethyl 3-methyl imidazolium acetate [(EMIM)Ac)] as a green catalyst via one-pot four-component condensation reaction o...

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Bibliographic Details
Published in:Polycyclic aromatic compounds 2023-04, Vol.43 (4), p.3761-3775
Main Authors: Katariya, Ashishkumar P, Katariya, Maya V., Sangshetti, Jaiprakash, Deshmukh, Satish U
Format: Article
Language:English
Subjects:
Acetic acid
biodegradable ionic liquid
Biodegradation
Carbonyl compounds
Carbonyls
Catalysts
Chemical synthesis
cleaner reaction profile
Condensation reaction
Ethanol
green Synthesis
Hydrazine
Hydrazines
Ionic liquids
Malononitrile
Pyrano[2,3-c] pyrazoles
Pyrazole
Pyrazoles
Substrates
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Summary:A Green, efficient and clean route for synthesis of biologically potent pyrano[2,3-c]pyrazole derivatives has been developed in excellent yield, by using biodegradable ionic liquid 1-ethyl 3-methyl imidazolium acetate [(EMIM)Ac)] as a green catalyst via one-pot four-component condensation reaction of ethyl-acetoacetate, hydrazine-hydrate, malononitrile and carbonyl compounds at reflux condition in ethanol. The striking features of the protocol are a cleaner reaction profile, mild experimental procedure, applicable to extensive range of substrates and short reaction time.
ISSN:1040-6638
1563-5333
DOI:10.1080/10406638.2022.2077775