Prophylaxis effects of water kefir on post‐infectious irritable bowel syndrome in rat model

Summary Water kefir (WK) is produced using WK grains containing beneficial bacteria and yeasts. It has antibacterial, anti‐inflammatory, anti‐diabetic, anti‐hyperlipidaemic, anti‐ulcerogenic, and antioxidant effects. The purpose of the research was to determine the effect of WK on irritable bowel sy...

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Bibliographic Details
Published in:International journal of food science & technology 2023-06, Vol.58 (6), p.3371-3378
Main Authors: Gökırmaklı, Çağlar, Erol, Zeki, Gun, Ilhan, Ozmen, Ozlem, Guzel‐Seydim, Zeynep Banu
Format: Article
Language:English
Subjects:
Animal models
Diabetes mellitus
Inflammation
Ingestion
Intestine
Irritable bowel syndrome
Kefir
lactic acid bacteria
Lymphocytes
Monocytes
pathology
Probiotics
Procalcitonin
Prophylaxis
water kefir
Yeasts
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Summary:Summary Water kefir (WK) is produced using WK grains containing beneficial bacteria and yeasts. It has antibacterial, anti‐inflammatory, anti‐diabetic, anti‐hyperlipidaemic, anti‐ulcerogenic, and antioxidant effects. The purpose of the research was to determine the effect of WK on irritable bowel syndrome (IBS). In this study, thirty‐two female Wistar‐Albino rats aged 3 months were randomly distributed to four groups: the control group (C), the WK group, the WK group with IBS (WK + IBS), and the IBS group. Results indicated that the IBS groups had higher white blood cell, lymphocyte, monocyte counts, and procalcitonin levels. The findings of WK + IBS group showed that WK improved against IBS. TNF‐α, NF‐kB expressions, and histopathological results significantly decreased after receiving WK treatment. In conclusion, ingestion of WK has prophylactic effects on IBS as exhibited through an in‐vivo murine model. The findings suggested that IBS may be prevented and treated with WK. All groups fed as ad libitum. Also, some of groups were supported with water kefir (WK) during 14 days. After 2 weeks, all rats were sacrificed and samples including bloods and tissues were collected for further analyses. According to the results, feeding with WK did not cause any adverse effects on test animals. WK administration resulted in a significant decrease in TNF‐α expressions, NF‐kB expressions, and histopathological findings. To sum up, WK showed prophylaxis effects on post‐infectious irritable bowel syndrome in rat model.
ISSN:0950-5423
1365-2621
DOI:10.1111/ijfs.16310