Preliminary evaluation of a 64Cu-labeled DNA aptamer for PET imaging of glioblastoma

To develop a DNA aptamer-based PET tracer for imaging of glioblastoma. 5 mM of NOTA-AS1411, 60-min, and 37 °C were selected as the optimal condition for 64 Cu radiolabeling of AS1411. 64 Cu-NOTA-AS1411 remained stable in PBS and 100% mouse serum for at least six hours. From the PET images, 64 Cu-NOT...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2023-06, Vol.332 (6), p.2279-2284
Main Authors: Li, Pinghui, Wang, Chunmei, Wang, Wenrui, Duan, Xiaoyan, Li, Jianbo
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Diagnostic Radiology
Hadrons
Heavy Ions
Imaging
Inorganic Chemistry
Nuclear Chemistry
Nuclear Physics
Physical Chemistry
Positron emission
Radiolabelling
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Summary:To develop a DNA aptamer-based PET tracer for imaging of glioblastoma. 5 mM of NOTA-AS1411, 60-min, and 37 °C were selected as the optimal condition for 64 Cu radiolabeling of AS1411. 64 Cu-NOTA-AS1411 remained stable in PBS and 100% mouse serum for at least six hours. From the PET images, 64 Cu-NOTA-AS1411 tended to be excreted out through the kidneys and there was high tracer accumulation in the bladder. There was a higher tumor uptake in the AS1411 group than that in the control group. 64 Cu-NOTA-AS1411 is a suitable potential PET tracer for imaging murine glioblastoma.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-023-08835-2