Acetmainophen Effect on Prostaglandin E2; A Mechanism for Patent Ductus Arteriosus Closure

The patent ductus arteriosus (PDA) has long been a treatment dilemma in the field of neonatology. Standard treatment regimens have considerable side effect profiles and surgical treatment carries significant risk to the neonate. Recent studies have demonstrated that acetaminophen may be a safe and e...

Full description

Saved in:
Bibliographic Details
Published in:Pediatrics (Evanston) 2017-09, Vol.140 (1_MeetingAbstract), p.52-52
Main Authors: Halliday, Matthew F, Williams, Shelly-Ann, Baatz, John E., Kiger, James, Halushka, Perry, Wagner, Carol L.
Format: Article
Language:English
Subjects:
Congenital diseases
Coronary vessels
Pediatrics
Prostaglandin E2
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The patent ductus arteriosus (PDA) has long been a treatment dilemma in the field of neonatology. Standard treatment regimens have considerable side effect profiles and surgical treatment carries significant risk to the neonate. Recent studies have demonstrated that acetaminophen may be a safe and effective alternative treatment to indomethacin for PDA closure. Currently, there are very few studies that have examined safety and pharmacologic mechanisms of acetaminophen in premature infants. We conducted a prospective study of premature infants with a PDA that were treated with either indomethacin or acetaminophen. Urine was collected prior to initiation of treatment and at two subsequent time points while on treatment, day 2 and day 4. Since acetaminophen is postulated to produce its beneficial effects to close the PDA via inhibition of prostaglandin synthesis, urinary PGE metabolite levels were measured via an ELISA assay.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.140.1MA.52