Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats

Purpose Natural antioxidants have gotten a lot of attention recently and they are found in a lot of plants. The goal of this study was to determine the antioxidant activities of Reissantia indica willd. (Mopane paddle-pod) plant extracts as well as their nephroprotective efficacy against paracetamol...

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Published in:Nutrire : revista de Sociedade Brasileira de Alimentação e Nutrição = journal of the Brazilian Society of Food and Nutrition 2023-05, Vol.48 (1), p.26, Article 26
Main Authors: Edo, Great Iruoghene, Ugbune, Ufuoma, Onoharigho, Favour Ogheneoruese, Ezekiel, Gracious Okeoghene, Agbo, Joy Johnson
Format: Article
Language:English
Subjects:
Analgesics
Antioxidants
Biological products
Clinical Nutrition
Creatinine
Flowers & plants
Food Science
Kidney diseases
Lipid peroxidation
Medicine
Medicine & Public Health
Nutrition
Reactive oxygen species
Rodents
Toxicity
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Summary:Purpose Natural antioxidants have gotten a lot of attention recently and they are found in a lot of plants. The goal of this study was to determine the antioxidant activities of Reissantia indica willd. (Mopane paddle-pod) plant extracts as well as their nephroprotective efficacy against paracetamol-induced nephrotoxicity. Methods Standard procedures were used to determine the extract's phytochemical composition and total phenolic content (TPC). Antioxidant capacity was evaluated using the ferric reducing antioxidant activity, nitric oxide and hydrogen peroxide scavenging, and phosphomolybdenum assays. For investigation of the nephroprotective effect, a total of 24 (200 -300 g) rats were divided into four groups of six rats (A, B, C, and D). To determine the effect of concurrent administration of R. indica on paracetamol nephrotoxicity, serum urea and creatinine were measured, as well as a lipid peroxidation, marker of malondialdehyde and antioxidant parameters (superoxide dismutase, reduced glutathione, glutathione-s-transferase, and catalase. Results Alkaloids, flavonoids, terpenoids, glycosides, coumarins, anthocyanidins, and isoflavonoids were found in plant extracts. R. indica had a TPC of 44.84 g/g gallic acid equivalents (GAE). For the creatinine level, there was no significant difference ( p  
ISSN:2316-7874
1519-8928
2316-7874
DOI:10.1186/s41110-023-00214-x