Electrochemical oxidative C(sp3)–H/O–H cross-coupling for the synthesis of α-acyloxyketones

C(sp3)–H/O–H cross-coupling represents an ideal strategy for constructing C(sp3)–O bonds but remains challenging due to the relatively inert C(sp3)–H bonds. Herein, we report a facile and novel electrochemical oxidative C(sp3)–H/O–H cross-coupling method, leading to various useful α-acyloxyketones w...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2023-05, Vol.10 (10), p.2459-2464
Main Authors: Wu, Jiwei, Shi, Haowen, Liu, Jianguo, Wang, Ruiyou, Zhou, Jie, Xiao-Lan, Xu, Hua-Jian, Xu
Format: Article
Language:English
Subjects:
Carboxylic acids
Cross coupling
Electrochemistry
Ketones
Organic chemistry
Oxidants
Oxidizing agents
Transition metals
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Summary:C(sp3)–H/O–H cross-coupling represents an ideal strategy for constructing C(sp3)–O bonds but remains challenging due to the relatively inert C(sp3)–H bonds. Herein, we report a facile and novel electrochemical oxidative C(sp3)–H/O–H cross-coupling method, leading to various useful α-acyloxyketones with moderate to excellent yields under transition metal- and oxidant-free conditions. A series of carboxylic acids including aromatic and aliphatic acids and ketones are compatible with this reaction.
ISSN:2052-4110
2052-4110
DOI:10.1039/d3qo00204g