Hollow carbon nanospheres loaded with upconversion nanoparticles for chemo-photothermal synergistic cancer therapy

Nanomaterials possess multidisciplinary capabilities in cancer diagnosis and treatment, including imaging and therapeutic, and thus have wide range of applications in the field of nanomedicine. To exploit these capabilities, herein we report a novel nanoplatform of upconversion nanoparticle (UCNPs)-...

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Bibliographic Details
Published in:Journal of materials science 2023-05, Vol.58 (19), p.8034-8046
Main Authors: Jiao, Xiaorui, Zhou, Wei, Akhtar, Mahmood Hassan, He, Di Demi, Zhou, Weiping, Yao, Lang, Zhang, Yun, Liu, Ning, Yu, Cong
Format: Article
Language:English
Subjects:
Antimitotic agents
Antineoplastic agents
Cancer
Cancer therapies
Carbon
Characterization and Evaluation of Materials
Chemistry and Materials Science
Chemotherapy
Classical Mechanics
Crystallography and Scattering Methods
Doxorubicin
Health aspects
In vivo methods and tests
Laboratories
Life sciences
Materials for Life Sciences
Materials Science
Nanomaterials
Nanoparticles
Nanospheres
Polymer Sciences
Solid Mechanics
Synergistic effect
Upconversion
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Summary:Nanomaterials possess multidisciplinary capabilities in cancer diagnosis and treatment, including imaging and therapeutic, and thus have wide range of applications in the field of nanomedicine. To exploit these capabilities, herein we report a novel nanoplatform of upconversion nanoparticle (UCNPs)-decorated hollow mesoporous carbon nanoparticles (HMCNs@UCNPs) prepared by a facile hydrothermal approach. Morphological and structural analyses of the newly synthesized nanomaterial were performed using high-resolution TEM (HR-TEM), XRD, and BET techniques. The porous nature of the HMCNs@UCNPs nanomaterial further assisted to load anticancer drug (DOX, doxorubicin) effectively. Hence, the DOX-modified nanoplatform HMCNs@UCNPs-DOX worked as a multimodal theranostic probe, concurrently demonstrating chemotherapeutic as well as photothermal effects subjected to NIR-stimulation. Additionally, synergistic effects of the developed nanoplatform were confirmed by in vitro and in vivo studies using MCF-7 cell line and mouse models, respectively. Graphical Abstract
ISSN:0022-2461
1573-4803
DOI:10.1007/s10853-023-08508-1