Study on Modification of Paclitaxel and Its Antitumor Preparation

Paclitaxel (PTX) was discovered more than 50 years ago in 1968. The drug, known as the first herbal-derived chemotherapeutic drug approved, works by inhibiting the cell cycle. However, due to its poor water solubility and non-selective toxicity, severe side effects often occur accompanied with the c...

Full description

Saved in:
Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2023-04, Vol.49 (2), p.288-297
Main Authors: Wenhao Zhou, Hu, Hongshang, Wang, Ting
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Drug delivery systems
Life Sciences
Organic Chemistry
Side effects
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Paclitaxel (PTX) was discovered more than 50 years ago in 1968. The drug, known as the first herbal-derived chemotherapeutic drug approved, works by inhibiting the cell cycle. However, due to its poor water solubility and non-selective toxicity, severe side effects often occur accompanied with the clinical application of drugs. How to enhance the efficacy of paclitaxel has become an urgent problem to researchers. Aiming to provide new ideas for structural modification and drug delivery system development, structural modification of paclitaxel, including the introduction of small molecular fragments or soluble polymers at the C-2' and C-7 sites and nanocarrier-based new generation PTX drugs Abraxane and Lipusu are discussed in this review.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162023020255