Salvation for Stalled Ribosomes

Ribosomes stall indefinitely at the 3′ end of the mRNAs that lack natural stop codon and also pause anywhere on normal mRNAs during starvation. This pausing traps a considerable population of ribosomes in an inactive state and leads to a deficiency of ribosomes for ongoing protein synthesis. Bacteri...

Full description

Saved in:
Bibliographic Details
Published in:Resonance 2023-01, Vol.28 (5), p.779-790
Main Authors: Nagarajan, T, Kumaran N Arul Muthu, Hussain, Munavar M
Format: Article
Language:English
Subjects:
Bacteriology
Molecular biology
Ribonucleic acid
RNA
Science education
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ribosomes stall indefinitely at the 3′ end of the mRNAs that lack natural stop codon and also pause anywhere on normal mRNAs during starvation. This pausing traps a considerable population of ribosomes in an inactive state and leads to a deficiency of ribosomes for ongoing protein synthesis. Bacteria possess a special RNA molecule called the tmRNA (a chimera of tRNA and mRNA), which in association with its binding partner SmpB protein, rescues the stalled ribosomes in a complex multistep process called trans-translation. This review aims to discuss the process of trans-translation and its involvement in regulating macromolecular processes in bacteria.
ISSN:0971-8044
0973-712X
DOI:10.1007/s12045-023-1605-5