Catalyst-Free Multicomponent Synthesis of Novel Chromene Carbonitriles from Pyrazole Aldehydes using Ethanol

A catalyst-free synthetic strategy to chromene carbonitriles by Multi-Component Reaction of pyrazole aldehydes, 5,5-dimethylcyclohexane-1,3-dione and malononitrile with ethanol, at room temperature is reported. Screening of solvents and purification of the compounds were also performed. The newly sy...

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Bibliographic Details
Published in:Oriental journal of chemistry 2022-10, Vol.38 (5), p.1156-1164
Main Authors: Jayanthi, Selvaraj, Sugumaran, Thangarajan, Monisha, Periyasamy, Gunasundar, Kittappa, Vetriselvan, Moorthy, Pramesh, Manickam, Venkatachalam, Ragunathan
Format: Article
Language:English
Subjects:
Aldehydes
Carbon
Catalysts
Chemical synthesis
Chemistry
Chromatography
Ethanol
Malononitrile
NMR
Nuclear magnetic resonance
Pyrazole
Room temperature
Spectral methods
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Summary:A catalyst-free synthetic strategy to chromene carbonitriles by Multi-Component Reaction of pyrazole aldehydes, 5,5-dimethylcyclohexane-1,3-dione and malononitrile with ethanol, at room temperature is reported. Screening of solvents and purification of the compounds were also performed. The newly synthesized novel compound’s (4H-chromene-3-carbonitriles) structures were authenticated by the spectral techniques viz. (1H , 13C)Nuclear Magnetic Resonance, FT-IR, and LC-MS analysis.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/380510