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Structural Characteristics and Anticancer Activity of Water-Soluble Polysaccharides from Vietnamese Brown Algae Sargassum microcystum and S. serratum
The composition of water-soluble polysaccharides (fucoidans and laminarans) from the two Vietnamese brown algae Sargassum microcystum and S. serratum was investigated. It was found that S. microcystum produced fucoidan and laminaran with predominance of the latter; S. serratum , only fucoidan. The f...
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| Published in: | Chemistry of natural compounds 2023, Vol.59 (1), p.1-5 |
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| creator | Surits, V. V. Shkrabov, R. A. Usoltseva, R. V. Khanh, H. H. N. Ermakova, S. P. |
| description | The composition of water-soluble polysaccharides (fucoidans and laminarans) from the two Vietnamese brown algae
Sargassum microcystum
and
S. serratum
was investigated. It was found that
S. microcystum
produced fucoidan and laminaran with predominance of the latter;
S. serratum
, only fucoidan. The fucoidans were sulfated galactofucans and a sulfated and acetylated heteropolysaccharide of complicated structure. The laminaran had a main chain of 1,3-bound
β
-D-glucose residues with single branches on C6 (ratio of 1,3:1,6 bonds = 4:1). The sulfates occupied the 2-, 4-, and 6-positions in the obtained sulfated laminaran derivative. A study of the biological activities of all obtained polysaccharides showed a lack of cytotoxicity and low activity against RPMI-7951 human melanoma cells with significantly more pronounced and selective activity against HuTu-80 human duodenum adenocarcinoma cells. |
| doi_str_mv | 10.1007/s10600-023-03905-z |
| format | article |
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Sargassum microcystum
and
S. serratum
was investigated. It was found that
S. microcystum
produced fucoidan and laminaran with predominance of the latter;
S. serratum
, only fucoidan. The fucoidans were sulfated galactofucans and a sulfated and acetylated heteropolysaccharide of complicated structure. The laminaran had a main chain of 1,3-bound
β
-D-glucose residues with single branches on C6 (ratio of 1,3:1,6 bonds = 4:1). The sulfates occupied the 2-, 4-, and 6-positions in the obtained sulfated laminaran derivative. A study of the biological activities of all obtained polysaccharides showed a lack of cytotoxicity and low activity against RPMI-7951 human melanoma cells with significantly more pronounced and selective activity against HuTu-80 human duodenum adenocarcinoma cells.</description><identifier>ISSN: 0009-3130</identifier><identifier>EISSN: 1573-8388</identifier><identifier>DOI: 10.1007/s10600-023-03905-z</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Algae ; Anticancer properties ; Cancer ; Care and treatment ; Chain branching ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Dextrose ; Glucose ; Organic Chemistry ; Plant Sciences ; Polysaccharides ; Sulfates ; Toxicity ; Water chemistry</subject><ispartof>Chemistry of natural compounds, 2023, Vol.59 (1), p.1-5</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c371t-ce0326b3272c62b95715dc987b9206e64a144b6a8b02178b7bb4946dd2c72633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Surits, V. V.</creatorcontrib><creatorcontrib>Shkrabov, R. A.</creatorcontrib><creatorcontrib>Usoltseva, R. V.</creatorcontrib><creatorcontrib>Khanh, H. H. N.</creatorcontrib><creatorcontrib>Ermakova, S. P.</creatorcontrib><title>Structural Characteristics and Anticancer Activity of Water-Soluble Polysaccharides from Vietnamese Brown Algae Sargassum microcystum and S. serratum</title><title>Chemistry of natural compounds</title><addtitle>Chem Nat Compd</addtitle><description>The composition of water-soluble polysaccharides (fucoidans and laminarans) from the two Vietnamese brown algae
Sargassum microcystum
and
S. serratum
was investigated. It was found that
S. microcystum
produced fucoidan and laminaran with predominance of the latter;
S. serratum
, only fucoidan. The fucoidans were sulfated galactofucans and a sulfated and acetylated heteropolysaccharide of complicated structure. The laminaran had a main chain of 1,3-bound
β
-D-glucose residues with single branches on C6 (ratio of 1,3:1,6 bonds = 4:1). The sulfates occupied the 2-, 4-, and 6-positions in the obtained sulfated laminaran derivative. A study of the biological activities of all obtained polysaccharides showed a lack of cytotoxicity and low activity against RPMI-7951 human melanoma cells with significantly more pronounced and selective activity against HuTu-80 human duodenum adenocarcinoma cells.</description><subject>Algae</subject><subject>Anticancer properties</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Chain branching</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Dextrose</subject><subject>Glucose</subject><subject>Organic Chemistry</subject><subject>Plant Sciences</subject><subject>Polysaccharides</subject><subject>Sulfates</subject><subject>Toxicity</subject><subject>Water chemistry</subject><issn>0009-3130</issn><issn>1573-8388</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kl2L1DAUhosoOK7-Aa8CXnnRMR9tkl6Ogx8LC4pd9DKk6WnN0jZrTqrO_g__rxlHWAZEcpFzwvPmcF7eonjO6JZRql4ho5LSknJRUtHQurx7UGxYrUSphdYPiw2ltCkFE_Rx8QTxJrdaSr0pfrUpri6t0U5k_9VG6xJEj8k7JHbpyW7JpV0cRLJzyX_36UDCQL7YjJVtmNZuAvIxTAe0zmW97wHJEMNMPntIi50BgbyO4cdCdtNogbQ2jhZxncnsXQzugCnXx1HtliDEaHP_tHg02Anh2d_7orh---Z6_768-vDucr-7Kp1QLJUOqOCyE1xxJ3nX1IrVvWu06hpOJcjKsqrqpNUd5UzpTnVd1VSy77lTXApxUbw4fXsbw7cVMJmbsMYlTzRcM60rSZm8p0Y7gfHLEFK2afbozE7VR9_rimVq-w8qnx7yomGBwef3M8HLM0FmEvxMo10RzWX76ZzlJzY7hhhhMLfRzzYeDKPmGABzCoDJATB_AmDuskicRJjhZYR4v91_VL8Bh1qzmg</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Surits, V. V.</creator><creator>Shkrabov, R. A.</creator><creator>Usoltseva, R. V.</creator><creator>Khanh, H. H. N.</creator><creator>Ermakova, S. P.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope></search><sort><creationdate>2023</creationdate><title>Structural Characteristics and Anticancer Activity of Water-Soluble Polysaccharides from Vietnamese Brown Algae Sargassum microcystum and S. serratum</title><author>Surits, V. V. ; Shkrabov, R. A. ; Usoltseva, R. V. ; Khanh, H. H. N. ; Ermakova, S. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-ce0326b3272c62b95715dc987b9206e64a144b6a8b02178b7bb4946dd2c72633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Algae</topic><topic>Anticancer properties</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Chain branching</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Dextrose</topic><topic>Glucose</topic><topic>Organic Chemistry</topic><topic>Plant Sciences</topic><topic>Polysaccharides</topic><topic>Sulfates</topic><topic>Toxicity</topic><topic>Water chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Surits, V. V.</creatorcontrib><creatorcontrib>Shkrabov, R. A.</creatorcontrib><creatorcontrib>Usoltseva, R. V.</creatorcontrib><creatorcontrib>Khanh, H. H. N.</creatorcontrib><creatorcontrib>Ermakova, S. P.</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><jtitle>Chemistry of natural compounds</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Surits, V. V.</au><au>Shkrabov, R. A.</au><au>Usoltseva, R. V.</au><au>Khanh, H. H. N.</au><au>Ermakova, S. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural Characteristics and Anticancer Activity of Water-Soluble Polysaccharides from Vietnamese Brown Algae Sargassum microcystum and S. serratum</atitle><jtitle>Chemistry of natural compounds</jtitle><stitle>Chem Nat Compd</stitle><date>2023</date><risdate>2023</risdate><volume>59</volume><issue>1</issue><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>0009-3130</issn><eissn>1573-8388</eissn><abstract>The composition of water-soluble polysaccharides (fucoidans and laminarans) from the two Vietnamese brown algae
Sargassum microcystum
and
S. serratum
was investigated. It was found that
S. microcystum
produced fucoidan and laminaran with predominance of the latter;
S. serratum
, only fucoidan. The fucoidans were sulfated galactofucans and a sulfated and acetylated heteropolysaccharide of complicated structure. The laminaran had a main chain of 1,3-bound
β
-D-glucose residues with single branches on C6 (ratio of 1,3:1,6 bonds = 4:1). The sulfates occupied the 2-, 4-, and 6-positions in the obtained sulfated laminaran derivative. A study of the biological activities of all obtained polysaccharides showed a lack of cytotoxicity and low activity against RPMI-7951 human melanoma cells with significantly more pronounced and selective activity against HuTu-80 human duodenum adenocarcinoma cells.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10600-023-03905-z</doi><tpages>5</tpages></addata></record> |
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| subjects | Algae Anticancer properties Cancer Care and treatment Chain branching Chemistry Chemistry and Materials Science Chemistry/Food Science Dextrose Glucose Organic Chemistry Plant Sciences Polysaccharides Sulfates Toxicity Water chemistry |
| title | Structural Characteristics and Anticancer Activity of Water-Soluble Polysaccharides from Vietnamese Brown Algae Sargassum microcystum and S. serratum |
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