In Vivo Study of Pre-treated Pumpkin Flour (Cucurbita moschata) Feeding Substitution on Hyperglycemic Male Wistar Rats (Rattus norvegicus)

Diabetes mellitus (DM) is a disease caused due to high blood sugar levels. Treatment for Diabetes mellitus patients can be supported through a suitable diet and nutrition intake. One of the potential plants used in a diabetic diet is pumpkin (Cucurbita moschata) which contains numerous bioactive com...

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Bibliographic Details
Published in:IOP conference series. Earth and environmental science 2023-05, Vol.1177 (1), p.12046
Main Authors: Putri, Widya Dwi Rukmi, Widyawati, Ana, Maligan, Jaya Mahar, Sunarharum, Wenny Bekti
Format: Article
Language:English
Subjects:
Bioactive compounds
Blanching
Blood
Blood glucose
Carotene
Citric acid
Cucurbita moschata
Diabetes mellitus
Diet
Flour
Glucose
Hyperglycemia
In vivo methods and tests
Males
Nutrition
Phenolic compounds
Phenols
Pumpkins
Rats
Substitutes
β-Carotene
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Summary:Diabetes mellitus (DM) is a disease caused due to high blood sugar levels. Treatment for Diabetes mellitus patients can be supported through a suitable diet and nutrition intake. One of the potential plants used in a diabetic diet is pumpkin (Cucurbita moschata) which contains numerous bioactive compounds such as fiber, beta-carotene, and phenolic compounds. This study was conducted to determine the effect of substitution feeding of pre-treated pumpkin flour, i.e., blanching (90°C, 6 min) or soaking under citric acid solution (0.1%, 60 min), on blood glucose levels of hyperglycemic male Wistar rats. The pre-treatment of results showed that the feeding substitution of 25% pre-treated pumpkin flour had reduced the blood glucose level of the hyperglycemic male Wistar rats group. The highest blood glucose reduction of 23.26% or 45.22 mg/dL was found in the rats fed with the substitution of 25% pumpkin flour treated with citric acid.
ISSN:1755-1307
1755-1315
DOI:10.1088/1755-1315/1177/1/012046