Synthesis and Effect of Substituted Pyrido[2,3-d]pyrimidine-2,4-diones on In Vitro Tumor DNA Methylation

Reaction of 3-diethylamino-1-aryl-, 3-diethylamino-1-aryl-2-phenyl(4-halophenyl)propane-1-ones hydrochlorides with 6-amino-1,3-dimethyluracil results in heterocyclization products, namely 1,3-dimethyl-7-aryl-5,6-dihydro-1 H -pyrido[2,3- d ]pyrimidine-2,4-diones, 1,3-dimethyl-7-aryl-6-phenyl(4-haloph...

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Bibliographic Details
Published in:Russian journal of general chemistry 2023-04, Vol.93 (4), p.795-799
Main Authors: Isakhanyan, A. U., Hakobyan, N. Z., Hovasyan, Z. A., Nersesyan, L. E., Aharonyan, A. S., Danielyan, I. S., Panosyan, Н. A., Harutyunyan, A. A.
Format: Article
Language:English
Subjects:
Aromatic compounds
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Diketones
Hydrochlorides
Tumors
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Summary:Reaction of 3-diethylamino-1-aryl-, 3-diethylamino-1-aryl-2-phenyl(4-halophenyl)propane-1-ones hydrochlorides with 6-amino-1,3-dimethyluracil results in heterocyclization products, namely 1,3-dimethyl-7-aryl-5,6-dihydro-1 H -pyrido[2,3- d ]pyrimidine-2,4-diones, 1,3-dimethyl-7-aryl-6-phenyl(4-halophenyl)-5,6-dihydro-1 H -pyrido[2,3- d ]pyrimidine-2,4-diones and 1,3-dimethyl-7-aryl-6-phenyl-(4-halophenyl)-1 H -pyrido[2,3- d ]pyrimidine-2,4-diones. The effect of the synthesized compounds on in vitro tumor DNA methylation was studied.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363223040047