Self-assembly in newly synthesized dual-responsive double hydrophilic block copolymers (DHBCs) in aqueous solution

Double hydrophilic diblock copolymers (DHBCs) with a zwitterionic block of poly[2-(methacryloyloxyethyl phosphorylcholine)] (PMPC) having degree of polymerization (DP) ( n  = 25) and other as thermo/pH-responsive poly[2-(dimethylaminoethyl methacrylate)] (PDMAEMA) block with DP ( n  = 24 and 48) abb...

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Bibliographic Details
Published in:Colloid and polymer science 2023-05, Vol.301 (5), p.417-431
Main Authors: Yukioka, Shotaro, Yusa, Shin-ichi, Prajapati, Virendra, Kuperkar, Ketan, Bahadur, Pratap
Format: Article
Language:English
Subjects:
Aqueous solutions
Block copolymers
Chain transfer
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Copolymers
Degree of polymerization
Drug delivery systems
Food Science
Hydrophilicity
Methacryloyloxyethyl phosphorylcholine
Molecular interactions
Nanotechnology and Microengineering
NMR
NMR spectroscopy
Nuclear magnetic resonance
Original Contribution
Physical Chemistry
Polymer Sciences
Polymerization
Polymers
Self-assembly
Simulation
Soft and Granular Matter
Synthesis
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Summary:Double hydrophilic diblock copolymers (DHBCs) with a zwitterionic block of poly[2-(methacryloyloxyethyl phosphorylcholine)] (PMPC) having degree of polymerization (DP) ( n  = 25) and other as thermo/pH-responsive poly[2-(dimethylaminoethyl methacrylate)] (PDMAEMA) block with DP ( n  = 24 and 48) abbreviated as PMPC 25 - b -PDMAEMA n were synthesized using reversible addition-fragmentation chain transfer (RAFT). The influence of the DP of the PDMAEMA block in both the DHBCs in different environments like pH, temperature, and salt concentration was studied exhaustively using proton nuclear magnetic resonance spectroscopy ( 1 H-NMR) and gel-permeation chromatography (GPC). Additionally, the molecular interaction between the blocks was predicted from the optimized descriptors using a computational simulation framework. The self-assembly leading to successive micellization is examined from scattering techniques in the applied stimuli environment. The micellization was favored in alkaline pH and in the presence of salt, particularly for the DHBC with a high DP. Graphical Abstract
ISSN:0303-402X
1435-1536
DOI:10.1007/s00396-023-05075-4