The association of high-fluoride and high-iodine combined exposure with dental fluorosis and goiter: a meta-analysis

It is controversial that high-fluoride and high-iodine combined exposure affects the prevalence of dental fluorosis and goiter. The aim of this study was to explore the potential association between high-fluoride and high-iodine combined exposure with dental fluorosis and goiter. We retrieved releva...

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Published in:Environmental geochemistry and health 2023-06, Vol.45 (6), p.3143-3153
Main Authors: Mou, Yahao, Qu, Tengjiao, Wang, Ruiyu, Zhang, Yulu, He, Zuoshun, Gu, Shiyan
Format: Article
Language:English
Subjects:
Analysis
Dental fluorosis
Earth and Environmental Science
Environment
Environmental Chemistry
Environmental Health
Exposure
Fluorides
Fluorosis
Geochemistry
Goiter
Health risks
Heterogeneity
Iodides
Iodine
Meta-analysis
Original Paper
Public Health
Risk assessment
Risk factors
Sensitivity analysis
Soil Science & Conservation
Statistical analysis
Statistical methods
Subgroups
Terrestrial Pollution
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Summary:It is controversial that high-fluoride and high-iodine combined exposure affects the prevalence of dental fluorosis and goiter. The aim of this study was to explore the potential association between high-fluoride and high-iodine combined exposure with dental fluorosis and goiter. We retrieved relevant articles from PubMed, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database and China Science and Technology Journal Database (VIP). The query format was 1 # “Fluorosis” OR “Fluoride,” 2 # “Iodine” OR “Iodide,” and 3 # 1 AND 2. A total of 20 papers were included in this study after independent review by two investigators. Our analysis showed that high-fluoride and high-iodine biphasic exposure was significantly associated with the prevalence of goiter (OR = 4.69, 95% CI 2.82–7.80, P  
ISSN:0269-4042
1573-2983
DOI:10.1007/s10653-022-01396-5