Designing Incubators for Cell Therapy Manufacturing

Optimizing growth conditions In the production of cells for human therapy, C02 incubators must provide a highly controlled environment to support optimal cell growth, ensuring proper gene expression, limiting stress responses, and preserving characteristics critical to the success of the therapy. Se...

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Bibliographic Details
Published in:Pharmaceutical technology Europe 2021-08, Vol.33 (8), p.30-33
Main Author: Bates, Mary Kay
Format: Article
Language:English
Subjects:
Cell culture
Cell growth
Chemicals
Design
Disinfection & disinfectants
Documentation
Gene expression
Good Manufacturing Practice
Humidity
Hydrogen peroxide
Manufacturers
Manufacturing
Microorganisms
Outdoor air quality
Preventive maintenance
Product recalls
Regulatory approval
Sensors
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Summary:Optimizing growth conditions In the production of cells for human therapy, C02 incubators must provide a highly controlled environment to support optimal cell growth, ensuring proper gene expression, limiting stress responses, and preserving characteristics critical to the success of the therapy. Sensors used to measure temperature, gas concentration, and relative humidity should be located inside the chamber where the cells are incubated, rather than using a bypass sensor located in a separate electronics compartment (4). Another design element critical to parameter recovery and uniformity of conditions in the incubator chamber is active air circulation. [...]hydrogen peroxide is a broad-spectrum disinfectant and, in low concentrations of 1-6%, it is generally compatible with paint, stainless steel, glass, and plastics.
ISSN:1753-7967