Interaction between Iron Nitrosyl Complexes and Phosphatidylcholine Membranes: A Fluorescence Study

Fluorescent probes: 8-anilino-1-naphthalenesulfonate (ANS), eosin Y, and pyrene were used to study the interaction between liposomes and three nitrosyl iron complexes that are promising anti-inflammatory agents and cardioprotectors. It was shown that the studied complexes compete with ANS molecules...

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Bibliographic Details
Published in:Russian Journal of Physical Chemistry A 2023-05, Vol.97 (5), p.822-827
Main Authors: Poletaeva, D. A., Faingold, I. I., Soldatova, Yu. V., Smolina, A. V., Savushkin, M. A., Sanina, N. A., Aldoshin, S. M.
Format: Article
Language:English
Subjects:
Chemical bonds
Chemistry
Chemistry and Materials Science
Fatty acids
Fluorescent indicators
Iron
Lipids
Liposomes
Phosphatidylcholine
Phospholipids
Physical Chemistry
Physics and Chemistry of Elementary Chemical Processes
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Summary:Fluorescent probes: 8-anilino-1-naphthalenesulfonate (ANS), eosin Y, and pyrene were used to study the interaction between liposomes and three nitrosyl iron complexes that are promising anti-inflammatory agents and cardioprotectors. It was shown that the studied complexes compete with ANS molecules for the bonding sites in a bilayer of liposomes. The incorporation of the complexes into the lipid bilayer was also studied according to the quenching of eosin Y and pyrene fluorescence. The data suggest that iron nitrosyl complexes interact with the phospholipids headgroups and can penetrate deeper into the hydrophobic center of a lipid bilayer, where they affect the packing of fatty acid chains. The pronounced membranotropic properties of the complexes correlated with their ability to inhibit lipid peroxidation. Complexes with high constants of pyrene bonding are the most effective antioxidants.
ISSN:0036-0244
1531-863X
DOI:10.1134/S0036024423050217