Recent Advances in the Catalytic Synthesis of 1,3‐Diamines

• Published in: ChemCatChem 2023-06, Vol.15 (11), p.n/a
• Main Authors: Yang, Beiqi, Yu, Aiwen, Wang, Yuanhua
• Format: Article
• Language: English
• Subjects: 1,3-diamine; amination; Chemical synthesis; C−H functionalization; Diamines; Intermolecular; Intramolecular; Nitrogen; Substrates
• ISSN: 1867-3880; 1867-3899
• DOI: 10.1002/cctc.202300141

1,3‐Diamines are important for many biologically active molecules, but there have been fewer studies on the synthesis of 1,3‐diamines than those on the synthesis of 1,2‐diamines. Relatively speaking, there are not sufficient reports on non‐catalytic methods in this direction. Among various methods, the catalytic construction of diamine products from nitrogen‐containing substrates is the most straightforward, but it suffers from the need to pre‐synthesize nitrogen‐containing substrates and is therefore narrowly used. For non‐specialized substrates, the direct construction of C−N bonds by metal‐ or non‐metal‐catalyzed C−H functionalization is undoubtedly the most efficient approach. This method is currently focused on monofunctionalization, but less has been reported for the simultaneous construction of multiple C−N bonds. Here, we summarize some innovative methods for the synthesis of 1,3‐diamines that have been developed in the past five years, encompassing various directions such as non‐catalytic reaction and metal‐ or non‐metal catalyzed reaction. Amination reactions: The present minireview summarizes the recent progress in 1,3‐diamines synthesis and provides the readers with representative strategies used in current studies, in particular the application of free radical tandem reactions in synthesis.