The association of myeloperoxidase and SYNTAX score in patients with ST-elevation myocardial infarction

Aims: There is evidence that myeloperoxidase (MPO) is a significant biomarker in various cardiovascular diseases. This work explored the relationship between MPO serum levels and SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery trial) score in patients with S...

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Published in:Gulhane Medical Journal 2023-06, Vol.65 (2), p.79-85
Main Authors: Kopytsya, Mykola, Rodionova, Iulia, Tytarenko, Nataliya, Kutia, Inna, Hilova, Yaroslava, Shelest, Borys
Format: Article
Language:English
Subjects:
Analysis
Angioplasty
Biomarkers
Blood pressure
Body mass index
C-reactive protein
Cardiac patients
Cardiology
Cardiovascular diseases
Care and treatment
Creatinine
Diabetes
Heart attack
Heart attacks
Hemoglobin
Inflammation
Informed consent
Laboratories
Leukocytes
Medical imaging
myeloperoxidase
Oxidative stress
prognosis
Regression analysis
Software
Statistical analysis
syntax score
Transluminal angioplasty
Triglycerides
Veins & arteries
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Summary:Aims: There is evidence that myeloperoxidase (MPO) is a significant biomarker in various cardiovascular diseases. This work explored the relationship between MPO serum levels and SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery trial) score in patients with ST Elevation Myocardial Infarction (STEMI) after percutaneous coronary intervention. Methods: The study design was observational and cross-sectional with prospective patient enrollment. Patients were divided into two groups: those with a SYNTAX score >32 and those with a SYNTAX score [less than or equal to] 32. The SYNTAX score was calculated based on the SYNTAX 2.2 score calculator (syntaxscore.org). Patients were analyzed for demographic, and clinical characteristics, including body mass index, carbohydrate and lipid metabolic balance, troponin, and MPO levels. The MPO was measured by ELISA. Results: Ninety-three patients with STEMI were enrolled with a mean age of 63.77 [+ or -] 8.55 years, and 50.5% were males. The MPO level had a significant positive correlation with the SYNTAX score in patients with SYNTAX score >32, r=0.58, p
ISSN:1302-0471
2146-8052
DOI:10.4274/gulhane.galenos.2022.58966