A chemometric approach based on a full factorial design to optimize terpene acylation using natural kaolin as eco‐friendly catalyst

A statistical approach was successfully applied to optimize the acylation of l‐menthol 1 in the presence of natural kaolin as an eco‐compatible catalyst. The influence of the main variation of the operating parameters, namely solvent volume, amount of the acyl donor, temperature and the catalytic ra...

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Bibliographic Details
Published in:Flavour and fragrance journal 2023-07, Vol.38 (4), p.274-284
Main Authors: Boukachabia, Mourad, Bendjeffal, Hacene, Khelassi, Mounia Merabet, Riant, Olivier
Format: Article
Language:English
Subjects:
Acetates
Acetic acid
Acylation
Alcohols
Catalysts
Confidence intervals
Data analysis
Design optimization
eco‐friendly catalyst
Factorial design
full factorial optimization
Gas chromatography
Kaolin
Menthol
monoterpene
natural kaolin
Parameters
Polynomials
Regression models
Solvents
Statistical analysis
Statistics
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Summary:A statistical approach was successfully applied to optimize the acylation of l‐menthol 1 in the presence of natural kaolin as an eco‐compatible catalyst. The influence of the main variation of the operating parameters, namely solvent volume, amount of the acyl donor, temperature and the catalytic rate of kaolin, was studied. A full factorial design (FFD) was used to search for the optimum of each parameter affecting the evolution of l‐menthol 1 acylation. A quadratic polynomial regression model was applied to analyse the experimental data with a p‐confidence level
ISSN:0882-5734
1099-1026
DOI:10.1002/ffj.3741