Sterehirsutynes A − C: three new acetylenic aromatic metabolites from Stereum hirsutum

Three new acetylenic aromatic compounds, sterehirsutynes A-C (1-3), along with three known congeners, frustulosinol (4), vibrayne (5), and sterehirsutinol (6), were isolated from the culture broth of Stereum hirsutum. Their structures were determined by detailed analyses of NMR and high-resolution m...

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Bibliographic Details
Published in:Natural product research 2023-07, Vol.37 (14), p.2367-2374
Main Authors: Liu, Fei, Li, Qin, Wei, Mengsha, Kang, Xin, Zhu, Hucheng, Sun, Weiguang, Chen, Chunmei, Zhang, Yonghui
Format: Article
Language:English
Subjects:
Acetylene - chemistry
Acetylene - pharmacology
Animals
aromatic alkyne
Aromatic compounds
Column chromatography
Congeners
Lipase - metabolism
Metabolites
NMR
Nuclear magnetic resonance
Pancreas - enzymology
porcine pancreatic lipase activities
Stereum hirsutum
Swine
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Summary:Three new acetylenic aromatic compounds, sterehirsutynes A-C (1-3), along with three known congeners, frustulosinol (4), vibrayne (5), and sterehirsutinol (6), were isolated from the culture broth of Stereum hirsutum. Their structures were determined by detailed analyses of NMR and high-resolution mass. Chiral column analysis showed that compounds 2 and 3 were racemic mixtures. These new compounds were evaluated for porcine pancreatic lipase (PPL) inhibitory activities, and compounds 1 and (±) 3 showed moderate inhibitory activity against PPL, with IC 50 values of 23.2 ± 1.04 and 21.8 ± 2.15 μM, respectively.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2047046