Copper‐Catalyzed Intramolecular SEAr Reaction–Oxidation under Aerobic Conditions: Synthesis of Styryl‐/Alkenyl‐Substituted Xanthone Derivatives

Herein, we report a copper‐catalyzed intramolecular electrophilic aromatic substitution (SEAr)−oxidation process to access a wide range of diversified xanthone derivatives using air as a sole oxidant. Specifically, this protocol affords hitherto unknown styryl‐/alkenyl‐substituted xanthone derivativ...

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Bibliographic Details
Published in:European journal of organic chemistry 2023-06, Vol.26 (23), p.n/a
Main Authors: Yadav, Sanjay, Kumar Sinha, Prashant, Suresh, Surisetti
Format: Article
Language:English
Subjects:
Copper
copper catalysis
cyclization
Oxidation
Oxidizing agents
SEAr reaction
styryl group
Substitution reactions
xanthone
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Summary:Herein, we report a copper‐catalyzed intramolecular electrophilic aromatic substitution (SEAr)−oxidation process to access a wide range of diversified xanthone derivatives using air as a sole oxidant. Specifically, this protocol affords hitherto unknown styryl‐/alkenyl‐substituted xanthone derivatives in moderate to high yields. The practicality of the method has been demonstrated by gram‐scale syntheses. Herein, we have designed and demonstrated a copper‐catalyzed intramolecular SEAr reaction−oxidation process to access styryl‐/alkenyl‐substituted xanthone derivatives. This protocol affords a variety of substituted xanthone derivatives in moderate to high yields. The protocol has been demonstrated by gram‐scale syntheses.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202300364