Effect of Hydrophilic Changes in Base Pair Mismatches on Deamination of Cytosine Photo-crosslinked to 3-Cyanovinylcarbazole

In this study, to understand the effects of base-pair mismatch on the deamination of cytosine cross-linked with 3-cyanovinylcarbazole, the complementary base of the target cytosine was changed from guanine (G) to adenine (A), thymine (T), cytosine (C), 5-methylcytosine (mC), and uracil (U). Notably,...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry letters 2023-04, Vol.52 (4), p.273-275
Main Authors: Sethi, Siddhant, Ishino, Kanako, Takeda, Kai, Nakamura, Shigetaka, Fujimoto, Kenzo
Format: Article
Language:eng ; jpn
Subjects:
Adenine
Thymine
Uracil
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, to understand the effects of base-pair mismatch on the deamination of cytosine cross-linked with 3-cyanovinylcarbazole, the complementary base of the target cytosine was changed from guanine (G) to adenine (A), thymine (T), cytosine (C), 5-methylcytosine (mC), and uracil (U). Notably, it was found that the fastest deamination of C to U occurs when C-C mismatching occurs.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.230055