Photoallosteric Polymersomes toward On‐Demand Drug Delivery and Multimodal Cancer Immunotherapy (Adv. Mater. 24/2023)

Cancer Immunotherapy In article number 2210986, Mingming Ding and co‐workers construct a photoallosteric polymersome (PAP) that undergoes a rapid conformational transition from β‐sheet to α‐helix upon exposure to near‐infrared light irradiation. Photoinduced allosteric behavior specifically enhances...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2023-06, Vol.35 (24), p.n/a
Main Authors: Zheng, Yi, Liu, Yang, Wu, Zhongchao, Peng, Chuan, Wang, Zuojie, Yan, Jingyue, Yan, Yue, Li, Zifen, Liu, Congcong, Xue, Jianxin, Tan, Hong, Fu, Qiang, Ding, Mingming
Format: Article
Language:English
Subjects:
Anticancer properties
cancer immunotherapy
conformation
drug delivery
Light irradiation
Materials science
Membrane structures
photoallosteric polymersome
polypeptide
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Summary:Cancer Immunotherapy In article number 2210986, Mingming Ding and co‐workers construct a photoallosteric polymersome (PAP) that undergoes a rapid conformational transition from β‐sheet to α‐helix upon exposure to near‐infrared light irradiation. Photoinduced allosteric behavior specifically enhances cell penetration and lysosome escape and reconstructs the vesicular membrane structure for on‐demand release of hydrophilic and hydrophobic drugs, thus remolding the immune microenvironment and achieving excellent synergistic anticancer efficacy in vivo without tumor recurrence and metastasis.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.202370172