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Kinetic Features of Elongation of Nucleic Acids as a Multistep Sequential Enzymatic Reaction

The kinetics of elongation of nucleic acids as a multistep sequential reaction forming a cycle was studied. A mathematically rigorous proof was given for the empirical formulas used to estimate the elongation time as a function of the length of the nucleotide chain. Estimates of the characteristic e...

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Bibliographic Details
Published in:Kinetics and catalysis 2023-04, Vol.64 (2), p.161-167
Main Authors: Lukovenkov, A. V., Bykov, V. I., Varfolomeev, S. D.
Format: Article
Language:English
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Summary:The kinetics of elongation of nucleic acids as a multistep sequential reaction forming a cycle was studied. A mathematically rigorous proof was given for the empirical formulas used to estimate the elongation time as a function of the length of the nucleotide chain. Estimates of the characteristic elongation time for typical chain lengths were proposed, including for the novel coronavirus (SARS-CoV-2). The stability of the elongation kinetics was investigated, and it was determined that, at typical chain lengths, increasing-amplitude unstable oscillating components appear along with the main exponential component.
ISSN:0023-1584
1608-3210
DOI:10.1134/S0023158423020040