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Kinetic Features of Elongation of Nucleic Acids as a Multistep Sequential Enzymatic Reaction
The kinetics of elongation of nucleic acids as a multistep sequential reaction forming a cycle was studied. A mathematically rigorous proof was given for the empirical formulas used to estimate the elongation time as a function of the length of the nucleotide chain. Estimates of the characteristic e...
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Published in: | Kinetics and catalysis 2023-04, Vol.64 (2), p.161-167 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | The kinetics of elongation of nucleic acids as a multistep sequential reaction forming a cycle was studied. A mathematically rigorous proof was given for the empirical formulas used to estimate the elongation time as a function of the length of the nucleotide chain. Estimates of the characteristic elongation time for typical chain lengths were proposed, including for the novel coronavirus (SARS-CoV-2). The stability of the elongation kinetics was investigated, and it was determined that, at typical chain lengths, increasing-amplitude unstable oscillating components appear along with the main exponential component. |
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ISSN: | 0023-1584 1608-3210 |
DOI: | 10.1134/S0023158423020040 |