Chromones from the Tobacco Derived Fungus Aspergillus versicolor and Their Antiviral Activity

Two new chromones, 8-(3-hydroxypropyl)-2-(3-hydroxy-1-oxopropyl)-6-methoxy-4 H -chromen-4-one ( 1 ), 2-acetyl-8-(3-hydroxypropyl)-6-methoxy-4 H -chromen-4-one ( 2 ), along with four known ones ( 3–6 ) were isolated from the fermentation products of an endophytic fungus Aspergillus versicolor derived...

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Published in:Chemistry of natural compounds 2023-05, Vol.59 (3), p.462-466
Main Authors: Shen, Si-Yu, Xiong, Wen, Li, Shan-Shan, Liu, Xiao-Shan, Li, Yin-Ke, Miao, Dong, Li, Xue-Mei, Wang, Wei-Guang, Du, Gang, Gong, Da-Ping, Hu, Qiu-fen, Ma, Xiao-Wei
Format: Article
Language:English
Subjects:
Antiviral agents
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Fungi
NMR
Nuclear magnetic resonance
Organic Chemistry
Plant Sciences
Tobacco
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Summary:Two new chromones, 8-(3-hydroxypropyl)-2-(3-hydroxy-1-oxopropyl)-6-methoxy-4 H -chromen-4-one ( 1 ), 2-acetyl-8-(3-hydroxypropyl)-6-methoxy-4 H -chromen-4-one ( 2 ), along with four known ones ( 3–6 ) were isolated from the fermentation products of an endophytic fungus Aspergillus versicolor derived from tobacco. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compounds 1 and 2 exhibited potential anti-TMV activities with inhibition rates of 35.3 and 30.6%, respectively, rates that are close to that of positive control.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-023-04024-5