Graphene quantum dots coated cationic polymer for targeted drug delivery and imaging of breast cancer

One of the important goals of cancer treatment in drug delivery systems (DSS) is to increase the concentration of the drug only around the tumor cells to prevent damage to normal cells. In this study, doxorubicin (DOX) was imprinted by the cationic polymer; Poly (methacrylic acid-co-diallyldimethyla...

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Bibliographic Details
Published in:Journal of polymer research 2023-07, Vol.30 (7), Article 268
Main Authors: Mirzababaei, Mahdi, Larijani, Kambiz, Hashemi-Moghaddam, Hamid, Mirjafary, Zohreh, Madanchi, Hamid
Format: Article
Language:English
Subjects:
Biocompatibility
Breast cancer
Cationic polymerization
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Damage prevention
Doxorubicin
Drug delivery systems
Drugs
Emission analysis
Field emission microscopy
Fourier transforms
Graphene
Graphite
Industrial Chemistry/Chemical Engineering
Infrared spectroscopy
Methacrylic acid
Nanoparticles
Original Paper
Polymer industry
Polymer Sciences
Polymers
Quantum dots
Toxicity
Vehicles
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Summary:One of the important goals of cancer treatment in drug delivery systems (DSS) is to increase the concentration of the drug only around the tumor cells to prevent damage to normal cells. In this study, doxorubicin (DOX) was imprinted by the cationic polymer; Poly (methacrylic acid-co-diallyldimethylammonium chloride) PMA DDA coated-GQDs. Chemical structure PMA DDA-coated GQDs was investigated and confirmed by using Fourier-transform infrared spectroscopy (FT-IR). Particle size and morphology of PMA DDA-coated GQDs was evaluated by Field Emission Scanning Electron Microscope (FE-SEM). Then the toxicity of PMA DDA-coated GQDs was investigated in vitro study. Also to evaluate the effectiveness of PMA DDA-coated GQDs in the living organism, Nanoparticles were injected into BALB/C mice containing 4T1 breast cancer cells. Then in vivo imaging was performed at the excitation wavelength of 400 nm and emission of 535 nm. The images showed that particles PMA DDA-coated GQDs had accumulated around the cancer cell.
ISSN:1022-9760
1572-8935
DOI:10.1007/s10965-023-03638-1