Enhancement of Dopamine Electrochemical Detection with Manganese Doped Crystalline Copper Oxide

Manganese doped crystalline copper oxide (CuO:Mn) and undoped CuO were prepared at room temperature by the hydrothermal method. The complete physico-chemical characterization of the materials was performed using X-ray diffraction (XRD), transmission/scanning electron microscopy (TEM/SEM), and X-ray...

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Bibliographic Details
Published in:Coatings (Basel) 2023-06, Vol.13 (6), p.1014
Main Authors: Guţoiu, Simona, Pogăcean, Florina, Măgeruşan, Lidia, Miclăuş, Maria Olimpia, Grad, Oana, Pană, Ioan-Ovidiu, Pruneanu, Stela
Format: Article
Language:English
Subjects:
Analysis
Biomedical materials
Biosensors
Cardiac glycosides
Cardiotonic agents
Catecholamines
Chloride
Copper oxide
Copper oxides
Cuprite
Diffraction
Dopamine
Electric properties
Electrochemical analysis
Electrodes
Enzymes
Etching
Manganese
Metal oxides
Nanoparticles
Oxidation
Phenols
Photoelectrons
Room temperature
Sensors
Software
Spectrum analysis
Voltammetry
X ray photoelectron spectroscopy
X-ray diffraction
X-ray spectroscopy
X-rays
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Summary:Manganese doped crystalline copper oxide (CuO:Mn) and undoped CuO were prepared at room temperature by the hydrothermal method. The complete physico-chemical characterization of the materials was performed using X-ray diffraction (XRD), transmission/scanning electron microscopy (TEM/SEM), and X-ray photoelectron spectroscopy (XPS). Furthermore, their analytical applicability was tested in electrochemical experiments for a dopamine assay. According to the morphological investigation, the materials had a flat structure with nearly straight edges. The XRD analysis proved the formation of the CuO phase with good crystallinity, while the Mn doping was determined by XPS to be around 1 at.%. Under optimized conditions, at pH 5.0, the CuO:Mn modified electrode (CuO:Mn/SPE) showed a high signal for dopamine oxidation, with a linear response in the 0.1–1 µM and 1–100 µM ranges and a low limit of detection of 30.3 nM. Five times higher sensitivity for manganese doped copper oxide in comparison with the undoped sample was achieved. The applicability of the developed CuO:Mn/SPE electrode was also tested in a commercially available pharmaceutical drug with good results, suggesting that the developed sensor has promising biomedical application potential.
ISSN:2079-6412
2079-6412
DOI:10.3390/coatings13061014