Synthesis and Biological Activity of 4-Aryl-2-hydroxy-4-oxo-N-(2-sulfamoylphenyl)but-2-enamides

The reaction of methyl esters of 4-aryl-2-hydroxy-4-oxobut-2-enoic (aroylpyruvic) acids with 2-aminobenzenesulfonamide in glacial acetic acid in the presence of anhydrous sodium acetate, 4-aryl-2-hydroxy-4-oxo- N -(2-sulfamoylphenyl)but-2-enamides were obtained. The analgesic and antimicrobial activ...

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Bibliographic Details
Published in:Russian journal of general chemistry 2023-05, Vol.93 (5), p.1023-1027
Main Authors: Gein, V. L., Nazarets, O. V., Romanova, A. V., Bobrovskaya, O. V., Novikova, V. V., Makhmudov, R. R., Balyukina, L. A.
Format: Article
Language:English
Subjects:
Acetic acid
Aromatic compounds
Biological activity
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Esters
Hydrochlorothiazide
Organic compounds
Sodium acetate
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Summary:The reaction of methyl esters of 4-aryl-2-hydroxy-4-oxobut-2-enoic (aroylpyruvic) acids with 2-aminobenzenesulfonamide in glacial acetic acid in the presence of anhydrous sodium acetate, 4-aryl-2-hydroxy-4-oxo- N -(2-sulfamoylphenyl)but-2-enamides were obtained. The analgesic and antimicrobial activity of the obtained compounds was studied.
ISSN:1070-3632
1608-3350
DOI:10.1134/S107036322305002X